Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 749-768 of 1673
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LOCALIZATION OF LIPOGENIC ENZYMES IN MICROPEROXISOMES FROM 3T3-L1 ADIPOCYTES (SUBCELLULAR FRACTIONATION)
(ProQuest Dissertations & Theses, 1984)At confluence, fibroblast-like 3T3-L1 cells undergo terminal differentiation acquiring the morphological and physiological characteristics of tissue adipocytes. Enzyme cytochemistry (Novikoff, et al., J. Cell Biol. 87:180, ... -
Localization of the discodermolide binding site in beta-tubulin
(ProQuest Dissertations & Theses, 2006)Discodermolide is one of the microtubule stabilizing drugs. It has similarities and differences from Taxol, which is the first drug identified to stabilize microtubules. Discodermolide has very strong hypernucleation effects ... -
Localized stimulation of the EGF receptor
(ProQuest Dissertations & Theses, 2004)In cancer, EGF plays a substantial role in inducing tumor cell movement. However, the mechanisms by which cells respond to concentration gradients of this chemoattractant are poorly understood. To model this process, we ... -
Long-term plasticity in hippocampus: Mechanisms of hypoxic adaptation and long-term depression of synaptic strength
(ProQuest Dissertations & Theses, 1997)Throughout evolution the mammalian brain has acquired many and varied strategies to protect itself against a variety of environmental insults, as well as mechanisms that mold neural function and architecture in response ... -
Long-term survival of basal forebrain cholinergic neurons in vivo: A test of the neurotrophic hypothesis
(ProQuest Dissertations & Theses, 1992)The degeneration of basal forebrain cholinergic neurons with corresponding reductions in cholinergic innervation to the neocortex is a characteristic neuropathological feature of Alzheimer's disease. The mechanism responsible ... -
Loop length matters: Effects of truncating the cytoplasmic M3M4 loop of the 5-HT3A receptors on channel function
(ProQuest Dissertations & Theses, 2010)The Cys-loop receptor family of neurotransmitter-gated ion channels forms receptors for acetylcholine, serotonin (5-HT), GABA and glycine. They are formed by the pentameric assembly of homologous subunits that share a ... -
Loss of astrocyte connexin 43 and 30 modulates CNS myelin and inflammation
(ProQuest Dissertations & Theses, 2010)In the mammalian brain, astrocytes express the gap junction (GJ) proteins connexin 43 (Cx43) and Cx30. These form junctions between astrocytes and astrocytes, astrocytes and oligodendrocytes, and astrocytes and myelin. ... -
Loss of cyclin A inhibition drives Drosophila R8 neurons into the cell cycle resulting in cytokinetic and axonal defects
(ProQuest Dissertations & Theses, 2012)Permanent cell cycle arrest in neurons remains poorly understood. It has been hypothesized that cell cycle activity disrupts neuronal cell fate determination, or alternatively that cell cycle activity disrupts neuronal ... -
Lupus and innate immunity: The macrophage as a potential therapeutic target
(ProQuest Dissertations & Theses, 2017)Systemic lupus erythematosus (SLE) is an autoimmune disease which manifests in multiple end organs including kidney (lupus nephritis, LN), skin (cutaneous lupus erythematosus, CLE), and brain (neuropsychiatric SLE, NPSLE). ... -
Lysosome destabilization as a therapeutic approach to apoptosis-resistant thyroid carcinoma
(ProQuest Dissertations & Theses, 2015)Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) are very aggressive and lethal neoplasms for which there is currently no effective treatment. Understanding mechanisms of intrinsic or ... -
M. smegmatis IKEPLUS Immunization Reveals the Mycobacterial Ribosome as a Source of Novel CD4+ T cell Antigens
(ProQuest Dissertations & Theses, 2018)No vaccine candidate has had major success in reducing the enormous global burden of disease due to Mycobacterium tuberculosis (Mtb). Critical to the control of Mtb is the ability of a vaccine to induce a strong CD4+ Tcell ... -
Macroautophagy and protein aggregate formation in lysosomal disease
(ProQuest Dissertations & Theses, 2013)Lysosomal diseases comprise a group of nearly 60 distinct disorders characterized by dysfunction of the lysosomal system. While most of these disorders present with systemic involvement, nearly two-thirds are associated ... -
Macroautophagy regulates CD4+ T cell function
(ProQuest Dissertations & Theses, 2011)Protein turnover is imperative for the diminution and removal of accumulated damaged proteins in the cell. Turnover is also essential to facilitate recycling of amino acids for new protein synthesis and to allow for the ... -
Major Facilitator Superfamily Domain-containing protein 2a is a novel PPAR-alpha target with roles in body growth, motor function, and lipid metabolism
(ProQuest Dissertations & Theses, 2012)Understanding how the body switches between storing and burning energy is fundamental to our ability to better treat metabolic disease. The metabolic adaptations to fasting in the liver are largely controlled by the nuclear ... -
Malaria parasite purine transporters: Function determination & inhibitor identification
(ProQuest Dissertations & Theses, 2013)Malaria is a disease that continues to affect hundreds of millions of people in tropical regions of the world every year. The parasite species Plasmodium falciparum and Plasmodium vivax cause the most virulent and prevalent ... -
Mapping functional domains in myosin
(ProQuest Dissertations & Theses, 1990)Two general approaches were taken to learn more about how structure relates to function in myosin. One approach involved the development of an expression system in which mutants of myosin could be generated and assayed. ... -
Mapping the functional surfaces of two signal transduction proteins
(ProQuest Dissertations & Theses, 2001)The modern methodology to characterize protein-ligand interactions at the atomic level encompasses structural, mutagenesis, and functional studies. This multidisciplinary approach has been employed to characterize the ... -
Mapping the membrane topology of the diphtheria toxin channel: A study in molecular cartography
(ProQuest Dissertations & Theses, 1994)Diphtheria Toxin (DT) is a 65 kD, two chain, protein. Its N-terminal A fragment kills cells by enzymatically inactivating their protein synthetic machinery, while its C-terminal B-fragment (40 kD) is required for binding ... -
Mapping the Solvent Accessible Surface Area of Proteins using Pyrite Nanocrystals: Bringing Oxidative Footprinting onto the Bench
(ProQuest Dissertations & Theses, 2016)Mapping the Solvent Accessible Surface Area of Proteins using Pyrite Nanocrystals: Bringing Oxidative Footprinting onto the Bench Mapping a protein's solvent accessible surface provides insight into structure and assembly ... -
Maternal systemic lupus erythematosus (SLE): Congenital cortical impairment and offspring sex ratio imbalance
(ProQuest Dissertations & Theses, 2008)