Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Author "Samuel, Raymond Edison"
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Mechanisms of sickle hemoglobin polymerization and gelation in the absence and in the presence of shear
(ProQuest Dissertations & Theses, 1992)Sickle cell disease is caused by a single amino acid substitution ({dollar}\beta{dollar}6:glu{dollar}\to{dollar}val) in the sickle hemoglobin (HbS) molecule. Upon deoxygenation, HbS molecules aggregate into solid, rope-like ...