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Title: Contrast sensitivity deficits in schizophrenia: A psychophysical investigation
Authors: Zemon, Vance
Herrera, Shaynna
Gordon, James
Revheim, Nadine
Silipo, Gail
Butler, Pamela
Keywords: contrast sensitivity (vision)
visual acuity
social impact
schizoaffective disorders
antipsychotic medication
sensory processing
spatial frequency
Visual perception
Issue Date: 2021
Publisher: Wiley-Blackwell
Citation: Zemon, V., Herrera, S., Gordon, J., Revheim, N., Silipo, G., & Butler, P. D. (2021). Contrast sensitivity deficits in schizophrenia: A psychophysical investigation. European Journal of Neuroscience, 53(4), 1155–1170.
Series/Report no.: European Journal of Neuroscience;53(4)
Abstract: Individuals with schizophrenia have problems with visual contrast processing. The current study investigated contrast sensitivity (CS) in schizophrenia/schizoaffective disorder to elucidate the underlying neural mechanisms affected by this disorder and to identify critical testing conditions that distinguish individuals with the disorder from healthy individuals. Principal component analysis was applied to the data (N = 143) to separate responses from distinct visual pathways. Participants were 68 patients and 75 age‐similar controls. CS was obtained using a forced‐choice psychophysical paradigm with grating patterns of low to high spatial frequency presented at short and long durations. Linear mixed‐effects models were used to examine differences in log CS with respect to group, duration, and stimulus condition. Lower CSs were found in patients compared to controls over all stimulus conditions with the magnitude of deficits dependent on both spatial frequency and stimulus duration. Log CSs to low and high spatial frequencies loaded onto separate principal components, supporting the existence of two psychophysical mechanisms, transient and sustained. Critical conditions were identified to tap each mechanism. Visual acuity was correlated moderately with log CS to high, but not low, spatial frequencies, and deficits found for acuity and CS to moderate/high spatial frequencies (4–21 cycles/degree) appear to reflect dysfunction in the sustained mechanism. CS deficits found at the lowest spatial frequency tested (0.5 cycles/degree) appear to reflect dysfunction in the transient mechanism. Both types of CS deficits may have diagnostic value and implications for social and neurocognitive deficits in this disorder. [ABSTRACT FROM AUTHOR] Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Description: Scholarly article
ISSN: 0953-816X
Appears in Collections:Ferkauf Graduate School of Psychology: Faculty Publications

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