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dc.contributor.authorHarris, Alexander Z.
dc.date.accessioned2018-07-12T17:34:57Z
dc.date.available2018-07-12T17:34:57Z
dc.date.issued2009
dc.identifier.citationSource: Dissertation Abstracts International, Volume: 69-04, Section: B, page: 2129.;Advisors: Diana L. Pettit.
dc.identifier.urihttps://yulib002.mc.yu.edu/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:3312072
dc.identifier.urihttps://hdl.handle.net/20.500.12202/968
dc.description.abstractReceptors located outside of the synapse are a ubiquitous but poorly understood feature of the nervous system. In this thesis, I investigate the sub-cellular distribution of N-methyl-D-aspartate receptors (NMDARs), a molecule critical for neural function, and explore the role extrasynaptic receptors play in neural communication. I have found that in hippocampal slices, extrasynaptic receptors represent a third of dendritic NMDARs, whose subunit composition is comparable to synaptic NMDARs. Furthermore, contrary to prior reports, these receptors form a stable non-mobile pool. Nonetheless, these receptors regularly participate in neural communication, augmenting synaptic strength in response to repetitive presynaptic activation. To test the effect of extrasynaptic NMDARs on plasticity, I took advantage of the fact that different types of physiologic bursts activate varying amounts of extrasynaptic NMDARs. I therefore incorporated these bursts into stimulation parameters for the induction of plasticity. I also measured the calcium flux that enters the cell during plasticity-induction protocols designed to recruit different amount of extrasynaptic NMDARs. Contrary to predictions based on previous work, I find that extrasynaptic receptors do not prevent LTP. Instead, I find that extrasynaptic NMDARs contribute a crucial component to the calcium signal necessary for the induction of plasticity.
dc.publisherProQuest Dissertations & Theses
dc.subjectNeurosciences.
dc.titleThe role of extrasynaptic NMDA receptors in synaptic transmission and plasticity
dc.typeDissertation


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