Predicting Response to Cancer Immunotherapy: Does Genomics Hold the Key?

Abstract

....This paper will begin by describing the history and mechanisms of the relationship between the immune system and cancer: how immunotherapy is a revolutionary treatment that turns the table from the principles of conventional cancer therapies. It will then describe the types of immunotherapies, with a focus on checkpoint blockade therapy. Finally, computational approaches to predicting response, specifically the feature of tumor mutational burden in predicting response to checkpoint blockade in melanoma and non-small cell lung cancer will be explored.