Prader Willi Syndrome: Past, Present, and Future

Abstract

Defined as a genetic disorder, Prader Willi Syndrome (PWS) occurs in 1 in 10,000 live births (Clarke, 1989). Almost all PWS patients present with obesity and hypotonia, with many suffering from diabetes and behavioral issues, such as skin picking, OCD tendencies, and angry outbursts. As of yet, there are no cures for this disorder, since it is caused by a genetic defect. However, there have been several attempts at symptomatic treatments for PWS, including behavioral and physical therapy. None have been successful at completely curing the different aspects, but there have been great strides made in treatment in PWS since its discovery in 1956. There are still many facets of the syndrome that are lacking proper research and treatment, which results in PWS patients not receiving the care that they require. Reexamining the discoveries made during its early years can bring to light overlooked aspects of Prader Willi and help guide future researchers in their search for a cure. By returning to the beginning and reevaluating the research, it will be possible to determine which treatments are most effective and which characteristics of Prader Willi are still left untouched.