Re-evaluating the Role of the piRNA Pathway in Germline Development in Drosophila.
Date
2018-05
Authors
Borck, Jacob J.
Journal Title
Journal ISSN
Volume Title
Publisher
Yeshiva College. Yeshiva University.
YU Faculty Profile
Abstract
The piRNA pathway has previously been shown to play a vital role in germline development in Drosophila through transposon repression. Through individualization complex staining and scoring techniques, fertility tests, and cytological analysis, this thesis focuses on expanding the understanding of the role of the piRNA pathway to include contributions to somatic stem cell development and to show the involvement of the RNAi pathway in spermatogenesis as well. A functional redundancy between the piRNA and RNAi pathways has been uncovered through these experiments as a result of an enhanced phenotype caused by simultaneous mutations in both pathways.
Description
The file is restricted for YU community access only.
Mentor: Josefa Steinhauer, Ph.D., Department of Biology
Keywords
piRNA pathway, germline development, RNAi pathway, Drosophila, somatic stem cell development
Citation
Re-evaluating the Role of the piRNA Pathway in Germline Development in Drosophila. Borck, Jacob J. Thesis submitted in partial fulfillment of the requirements of the Jay and Jeanie Schottenstein Honors Program, Yeshiva College, Yeshiva University, May 2018.