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https://hdl.handle.net/20.500.12202/9408
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DC Field | Value | Language |
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dc.contributor.author | Seng, Elizabeth | |
dc.contributor.author | Cohen, Jenna N. | |
dc.contributor.author | Foley, Frederick W. | |
dc.date.accessioned | 2023-10-31T15:14:31Z | |
dc.date.available | 2023-10-31T15:14:31Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Cohen, J. N., Seng, E., & Foley, F. W. (2021). Cognitive and motor slowing mediate the relationship between depression and falls in multiple sclerosis patients. Multiple Sclerosis and Related Disorders, 50, 102808. https://doi.org/10.1016/j.msard.2021.102808 | en_US |
dc.identifier.issn | 2211-0348 | |
dc.identifier.uri | https://ezproxy.yu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,sso&db=edselp&AN=S2211034821000742&site=eds-live&scope=site | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12202/9408 | |
dc.description | Scholarly article | en_US |
dc.description.abstract | __Objective__ Given the limited research concerning the relationship between depression and falls in multiple sclerosis (MS), this study aimed to examine the direct and indirect association between fall history and depressive symptoms. __Methods__ One hundred and forty seven MS patients had completed at least one neuropsychological assessment that included detailed information regarding fall history, as well as measures of depression, motor function, and cognitive processing speed. __Results__ Fall history was associated with higher depressive symptoms and poorer overall motor function. Higher self-reported depressive symptoms were associated with higher odds of falls in the last year (OR = 1.64, 95% CI 1.16, 2.31) in an age adjusted model. Cognitive and motor slowing serially mediated the relationship between depressive symptoms and fall history (estimate = 0.060, 95% CI = 0.01, 0.15). __Conclusions__ With the extensive research on the cognitive and motor correlates of falls in MS, our findings suggest that depressive symptoms are also associated with falls in people with MS. Moreover, this study provides preliminary support for a pathway by which depressive symptoms are related to falls in part through their relationships with cognitive and motor slowing. | en_US |
dc.description.sponsorship | __Declaration of Competing Interest__ Dr. Seng receives research support from the NINDS (K23 NS096107 PI: Seng) and has consulted for GlaxoSmithKline, Eli Lilly, and Click Therapeutics. Dr. Seng has received travel funds from the American Psychological Association, the American Academy of Neurology, the American Association of Pain Medicine Foundation, and the American Headache Society. Dr. Foley has consulted for Berlex, Biogen, and Roche. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartofseries | Multiple Sclerosis and Related Disorders;50 | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Multiple sclerosis | en_US |
dc.subject | Falls | en_US |
dc.subject | Depressive symptoms | en_US |
dc.subject | Processing speed | en_US |
dc.subject | Motor function | en_US |
dc.title | Cognitive and motor slowing mediate the relationship between depression and falls in multiple sclerosis patients | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.msard.2021.102808 | en_US |
dc.contributor.orcid | 0000-0002-8938-4949 | en_US |
local.yu.facultypage | https://www.yu.edu/faculty/pages/seng-elizabeth | en_US |
local.yu.facultypage | https://www.yu.edu/faculty/pages/foley-frederick | |
Appears in Collections: | Ferkauf Graduate School of Psychology: Faculty Publications |
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