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Transcriptional Dynamics During Lens Fiber Cell Differentiation and Novel Insights Into Their Denucleation Process (ProQuest Dissertations & Theses Global, 2018)The temporal and spatial regulation of gene transcription is a central process governing mammalian development and differentiation. Cellular differentiation is executed through coordinated expression of multiple genes, ...
The Role of Heparan Sulfate Proteoglycans as Co-Receptors of Wnt-signaling during Neural Development. (ProQuest Dissertations & Theses Global, 2018)Cell migration is a hallmark of many biological processes, including development, immunity, and malignancies. In particular, structures part of the nervous system, including synapses and circuitries, are formed and maintained ...
(ProQuest Dissertations & Theses Global, 2018)Variation of DNA sequence in the human genome has relatively predictable effects in protein-coding sequences, but is not well understood in the remaining 98% of the genome. A current focus of research is on the sites that ...
(ProQuest Dissertations & Theses Global, 2018)The potential of stem cell-based therapeutics has reignited interest and attention to the development of organs and cell fate specification. In patients, irreversible vision loss occurs due to neurodegenerative eye disease. ...