Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.12202/9609
Title: | Mechanism and color modulation of fungal bioluminescence |
Authors: | Oliveira, Anderson G. Kaskova, Zinaida M. Petushkov, Valentin N. Purtov, Konstantin V. Rodionova, Natalja S. Mineev, Konstantin S. Guglya, Elena B. Kotlobay, Alexey Baleeva, Nadezhda S. Yampolsky, Ilia V. Baranov, Mikhail S. Arseniev, Alexander S. Gitelson, Josef I. Lukyanov, Sergey Suzuki, Yoshiki Kanie, Shusei Pinto, Ernani Di Mascio, Paolo Waldenmaier, Hans E. Pereira, Tatiana A. Carvalho, Rodrigo P. Oba, Yuichi Bastos, Erick L. Stevani, Cassius V. Yampolsky, Ilia V. 0000-0003-1752-0726 |
Keywords: | Fungal Proteins/chemistry indoles/chemistry Luciferases/chemistry Pyrazines/chemistry Fungal Proteins/metabolism Indoles/metabolism Luciferases/metabolism Pyrazines/metabolism Pyrones/chemistry |
Issue Date: | 2017 |
Publisher: | American Association for the Advancement of Science |
Citation: | Mechanism and color modulation of fungal bioluminescence ZM Kaskova, FA Dörr, VN Petushkov, KV Purtov, AS Tsarkova, ... Science advances 3 (4), e1602847 |
Series/Report no.: | Science advances;3(4) |
Abstract: | Bioluminescent fungi are spread throughout the globe, but details on their mechanism of light emission are still scarce. Usually, the process involves three key components: an oxidizable luciferin substrate, a luciferase enzyme, and a light emitter, typically oxidized luciferin, and called oxyluciferin. We report the structure of fungal oxyluciferin, investigate the mechanism of fungal bioluminescence, and describe theuseof simple synthetic a-pyrones as luciferins to produce multicolor enzymatic chemiluminescence. A high-energy endoperoxide is proposed as an intermediate of the oxidation of the native luciferin to the oxyluciferin, which is a pyruvic acid adduct of caffeic acid. Luciferase promiscuity allows the use of simple a-pyrones as chemiluminescent substrates. |
Description: | Scholarly article / Open access |
URI: | https://hdl.handle.net/20.500.12202/9609 https://doi.org/10.1126/sciadv.1602847 |
ISSN: | 2375-2548 |
Appears in Collections: | Stern College for Women -- Faculty Publications |
Files in This Item:
File | Description | Size | Format | |
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Oliveira OA 2017 Mechanism and color sciadv.1602847.pdf | 472.63 kB | Adobe PDF | View/Open |
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